Sunday, February 10, 2013

Tycoon World Of Warcraft Gold Addon - ATK Gaming Community


Gold Addon Automates The Most Powerful Gold Strategies In The Game And Generates You Nearly 30,000g Per Day On Autopilot!

Here?s the truth about every WoW gold-making site or guide: They?re all based on gimmicky tactics using a specific server?s economy.

Usually it?s a server that has an economy that favors the seller, so they can make mountains of gold without a lot of work.

They exploit hot items for a short period of time and try to make you think you can replicate their success year-round.

And the simple fact is that what makes you gold today might not make you gold tomorrow.

You Need An Automated, Gold-Making System That Uses Solid, Proven Strategies Unique To Your Server To Rake In The Gold On Autopilot....More

Source: http://www.atkcommunity.com/showthread.php/3529-Tycoon-World-Of-Warcraft-Gold-Addon

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FOX40 has an opening for a graphic artist | KTXL FOX40

FOX40?s Creative Services team is looking for a full-time Graphic Artist to help extend our brand through print, interactive, animation and on-air graphic presentation. We?re looking for someone who can conceptualize, design and execute graphic designs and who will be responsible for maintaining and enforcing the FOX40 visual brand. An eye for superior design is essential, as well as strong Photoshop skills. You must have a background in graphic design, with a working knowledge of Aftereffects, Photoshop, Illustrator, and 3D Studio Max. If you have a strong sense of layout, accuracy, consistency, professionalism and a reputation as a graphics problem-solver, this opportunity is the perfect fit. Formal graphic design education or equivalent broadcast industry experience is required. No beginners please.

To see a complete job description and required skills, and to apply online, go to TribJobs.com.

Source: http://fox40.com/2013/02/08/graphic-artist-id24013/

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Saturday, February 9, 2013

First Person: Digging Out from Nemo in Western Massachusetts

Yahoo! News is gathering brief first-person accounts, photos and video from the severe winter weather in the northeastern United States. Here's one resident's story.

FIRST PERSON | WESTERN MASSACHUSETTS -- The snow started Friday afternoon, the nice kind of snow that's fun to play in. My family and I took a walk through our neighborhood with our 2-year old, who had a blast running along the lightly dusted sidewalks.

Saturday morning, that walk is a cardio workout. The local news says Springfield got 15 inches of snow overnight. But the snow is almost up to my knees on our side street, making the total more like 20 to 22 inches. We live right off a major street, which saw regular plowing all night. While that's good, it also means there's a four foot pile of snow blocking our street in.

We consider ourselves lucky. We still have power, and if we had to get out, we could probably force our way through the snow eventually. It could have been much worse. I grew up just outside Boston, and was six years old during the Blizzard of '78. We lived a few hundred yards from the ocean, and got flooded on top of the snow. Here in western Massachusetts, we don't have anything like that to contend with. Even compared to the Halloween ice storm in 2011, Nemo isn't as bad. The trees aren't snapping in half and threatening to fall on us this time.

So we got lucky. The folks I'm worried about are out east. My elderly mother still lives in our family home. Hopefully, the storm surge will spare her part of the beach this time.

Source: http://news.yahoo.com/first-person-digging-nemo-western-massachusetts-201800667.html

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APNewsBreak: Tyler to testify on HI celeb privacy

HONOLULU (AP) ? Aerosmith frontman Steven Tyler plans to attend a legislative hearing in Hawaii on Friday on a bill that bears his name and would limit people's freedom to take photos and video of celebrities.

Hawaii's Senate Judiciary Committee plans to consider the so-called Steven Tyler Act on Friday morning, the first time lawmakers will discuss the bill publicly.

A publicist for the former "American Idol" judge told The Associated Press on Thursday that Tyler submitted written testimony supporting the proposal, which would allow people to collect damages from someone who photographs them in an offensive way during their personal or family time.

"The paradise of Hawaii is a magnet for celebrities who just want a peaceful vacation," Tyler said in a statement emailed to The Associated Press. "As a person in the public eye, I know the paparazzi are there and we have to accept that. But when they intrude into our private space, disregard our safety and the safety of others, that crosses a serious line that shouldn't be ignored."

More than a dozen celebrities have submitted testimony supporting the bill, including Britney Spears, Avril Lavigne, Neil Diamond, Tommy Lee and the Osborne family. The letters all included the same text.

The stars say paparazzi have made simple activities like cooking with family and sunbathing elusive luxuries and the bill would give them peace of mind.

"Providing a remedy to the often-egregious acts of the paparazzi is a very notable incentive to purchase property or vacation on the islands," the stars said. "Not only would this help the local economy, but it would also help ensure the safety of the general public, which can be threatened by crowds of cameramen or dangerous high-speed car chases."

Hawaii Gov. Neil Abercrombie says he supports the intent of the bill but says it may need to be refined. He says the state attorney general will testify about legal concerns concerning the bill's language.

Sen. Kalani English, from Maui, says he introduced the bill at the request of Tyler, who owns a multimillion-dollar home in Maui. More than two-thirds of the state's senators have co-sponsored the bill.

English says the bill will spur celebrity tourism to the islands, boosting Hawaii's economy.

Opponents say the bill could be unconstitutional.

Laurie Temple, an attorney at the American Civil Liberties Union, said Thursday the bill would punish freedoms of expression protected by the First Amendment.

She said lawmakers should support better enforcement of current stalking laws rather than passing new legislation.

The National Press Photographers Association said the bill is "well-meaning but ill-conceived" and tramples on constitutional rights.

The New York-based organization represents numerous national media organizations with its letter, including the Society of Professional Journalists, the Associated Press Media Editors and the American Society of News Editors.

The Motion Picture Association of America also opposes the bill.

Among other objections, the association says the bill could make it harder to police movie piracy, because there's no exemption for law enforcement who might want to take photos or video of people they're investigating.

The bill would open up photographers, videographers and distributors to civil lawsuits if they take, sell or disseminate photos or videos of someone during private or family moments "in a manner that is offensive to a reasonable person."

The bill doesn't specify whether public places, like Hawaii's beaches, would be exempt. The bill says it would apply to people who take photos from boats or anywhere else within ocean waters.

English says the bill is not intended to limit beach photos. But he says Tyler has had paparazzi hide in his bushes to take photos of him inside his house.

Photos of vacationing stars in swimsuits have long been a fixture in tabloids and celebrity magazines.

The state's largest newspaper, the Honolulu Star-Advertiser, published an editorial Thursday that called lawmakers who support the bill "star-struck."

The newspaper said the bill might not affect only journalists.

"It could also make lawbreakers out of anyone taking photographs in public places, be it an ordinary photojournalist or someone with a camera phone," the editorial said.

___

Anita Hofschneider can be reached at http://twitter.com/ahofschneider .

Source: http://news.yahoo.com/apnewsbreak-tyler-testify-hi-celeb-privacy-014019772.html

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New drug is first to help patients with recurrent low-grade ovarian cancer

Feb. 8, 2013 ? Low-grade serous ovarian cancer is less common and aggressive than the high-grade variety, yet exceptionally difficult to treat when frontline therapy fails.

"After surgery, with or without pre-surgical chemotherapy, when low-grade serous ovarian cancer persists or returns, chemotherapy and hormonal therapy are relatively ineffective," said David Gershenson, M.D., professor in The University of Texas MD Anderson Cancer Center Department of Gynecological Oncology and Reproductive Medicine.

Response rates for treatment are measured in single digits. Gershenson and colleagues have spent the greater part of 20 years characterizing the disease, which makes up 10 percent of ovarian cancer cases, and searching for new ways to treat it. Cancer recurs or persists in 80 to 85 percent of patients.

A phase II clinical trial by the National Cancer Institute's Gynecological Oncology Group provides the first evidence of a drug that shows a relatively high response rate for these patients.

Selumetinib halts growth or shrinks tumors

In the first-targeted therapy clinical trial for low-grade serous ovarian cancer, eight of 52 (15 percent) patients had a complete or objective partial response (tumor shrinkage) and 34 (65 percent) had no disease progression during the two-year course of the study. Study results appear in the February edition of The Lancet Oncology.

"These are remarkably encouraging results for what can ultimately be a devastating disease," said Gershenson, the paper's senior author.

These patients have a median overall survival of 80 months, about twice as long as those with high-grade disease, who are typically in their 60s when diagnosed and comprise 90 percent of ovarian cancer patients. The average age of women with low-grade cancer falls in the early 40s, Gershenson said, and it's not uncommon to see women in their 20s, 30s and 40s and the occasional teenager with the disease.

High-grade serous ovarian cancer is susceptible to chemotherapy upon relapse or recurrence.

Median overall survival not reached

Cancer-causing genetic mutations in BRAF and KRAS genes occur more frequently in low-grade ovarian cancer, so the researchers chose a drug that targets the molecular network that includes those genes.

Selumetinib inhibits MEK1/2, a critical molecule in what's known as the MAPK pathway, which includes BRAF and KRAS.

All 52 patients had received at least one previous therapy, with 30 having had three or more. Clinical trial results with selumetinib include:

* Median progression-free survival of 11 months and 34 patients (65 percent) went at least six months without their disease worsening.

* Two-year overall survival of 55 percent.

* Median overall survival had not been reached, because more than half of patients (61 percent) remained alive at the time of data cutoff for the study.

* No treatment-related deaths.

Side effects ranged from cardio and gastrointestinal toxicity to pain, fatigue, anemia and dermatological effects. Of the 52 patients, 22 had their doses reduced and 13 ultimately left the study due to side effects.

Researchers obtained tumor samples sufficient for DNA analysis from 34 patients. While 14 patients had KRAS mutations and two had BRAF mutations, there was no connection between having those mutations and whether the patients responded to selumetinib.

Gershenson said researchers will further explore the question of matching drug to mutation during a larger phase 2/3 clinical trial that he will lead with investigators from the NCI Gynecological Oncology Group and the United Kingdom. The study will enroll 250 patients and is likely to begin later this summer.

Phase 2 trials generally do not include a control or comparison group, but the team noted treatment results for 58 women not in the trial who were treated at MD Anderson with current options. Between them, these patients received 108 different chemotherapy regimens, which produced one complete and three partial responses for an overall response rate of 3.7 percent.

A step toward personalized therapy for ovarian cancer

In an accompanying commentary, Sven Mahner, M.D., and Jacobus Pfisterer, M.D., Ph.D., German oncologists who did not participate in the research, note that the study is a step toward individualized treatment for ovarian cancer that reflects important molecular differences between low-grade and high-grade disease.

The response rate and disease stabilization rate are "particularly promising in a setting of heavily pretreated recurrent disease."

"A strength of the study is mandatory reference pathology of recurrent disease to ensure exclusion of patients with progression to high-grade disease, who are likely to benefit from chemotherapy, and recurrent borderline ovarian tumors that have excellent prognosis with salvage surgery alone," Mahner and Pfisterer wrote.

Co-authors with Gershenson are first author John Farley, M.D., of Creighton University School of Medicine at St. Joseph's Hospital in Phoenix; William Brady, Ph.D., and Heather Lankes Ph.D., of Roswell Park Cancer Institute in Buffalo, N.Y.; Vinod Vathipadiekal, Ph.D., and Michael Birrer, M.D., of Massachusetts General Hospital, Boston; Robert Coleman, M.D., MD Anderson's Department of Gynecological Oncology; Mark Morgan, M.D., Fox Chase Cancer Center, Philadelphia; Robert Mannel, M.D., of University of Oklahoma Health Sciences Center, Oklahoma City; S. Diane Yamada, M.D., University of Chicago; David Mutch, M.D., Washington University School of Medicine, St. Louis, Mo., and William Rodgers, M.D., Lenox Hill Hospital, New York.

The clinical trial was sponsored by the Cancer Therapy Evaluation Program of the National Cancer Institute and funded by NCI grants (CA 27469 and CA 37517) to the Gynecological Oncology Group.

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The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/4Ed9BZ9PWxs/130208152711.htm

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Friday, February 8, 2013

Monster blizzard threatens Northeast

BOSTON (Reuters) - The northeastern United States braced on Friday morning for a blizzard that could drop up to three feet (nearly one meter) of snow through Saturday and bring travel to a halt.

Blizzard warnings were in effect from New Jersey through southern Maine, with Boston expected to bear the brunt of the massive storm that could set records. The day began with light snow and winds that were due to pick up with much heavier snowfall by afternoon.

Officials urged residents to stay home, rather than risk getting stuck in deep drifts or whiteout conditions.

Boston and surrounding communities said schools would be closed on Friday, and city and state officials told nonessential city workers to stay home. Businesses were urged to let staff work from home or shorten schedules.

"Accumulation is expected to be swift, heavy and dangerous," Massachusetts Governor Deval Patrick told reporters. "I am ordering all nonessential state workers to work from home (Friday). I am strongly urging private employers to take the same precautions."

Officials across the region echoed his recommendations, telling residents to prepare for any power outages and consider checking on elderly or disabled neighbors who might need help.

In New York City, still not fully recovered from the effects of October's devastating Hurricane Sandy, officials said they had 1,800 Sanitation Department trucks equipped with snow plows ready to be deployed.

In New Jersey, also hit hard by Sandy, state officials expected major coastal flooding, high winds, and possible blizzard conditions in the northeastern section of the state.

"This is a dangerous storm, and we ask motorists to be careful while driving. There is also the potential for downed trees and wires because of wind conditions," said Colonel Rick Fuentes, director of the New Jersey Office of Emergency Management. "(The) evening commute will be treacherous throughout much of New Jersey."

The National Weather Service, warning of a "major, maybe even historic, snowstorm," said Boston and much of New England could get up to three feet of snow on Friday and Saturday, its first heavy snowfall in two years. Winds could gust as high as 60 miles to 70 miles per hour (95 to 112 km per hour).

If more than 18.2 inches of snow falls in Boston, it will rank among the city's 10 largest snowfalls. Boston's record snowfall, 27.6 inches, came in 2003.

Cities from Hartford, Connecticut, to Portland, Maine, were expected to see at least one foot of snow.

Airlines have already canceled nearly 2,500 flights for Friday, according to website FlightAware.com, with the largest number of cancellations at airports in Newark, New Jersey; New York City; Chicago and Boston.

Some 550 flights were canceled for Saturday, according to the flight-tracking site.

Boston's Logan International Airport warned that once the storm roars in, all flights would likely be grounded for 24 hours.

United Continental Holdings Inc, JetBlue Airways Corp and Delta Air Lines Inc all reported extensive cancellations.

ECHOES OF '78

For some in the Boston area, the forecast brought to mind memories of the blizzard of 1978, which dropped 27.1 inches, the second largest snowfall recorded in the city's history. That storm started out gently and intensified during the day, leaving many motorists stranded during the evening commute.

Dozens of deaths were reported in the region after that storm, many from people touching downed electric lines.

Officials warned of a high risk of extensive power outages across the region due to the combination of heavy snow and high winds. Residents were also at risk of losing heat at a time when temperatures would dip to 20 Fahrenheit (minus 7 Celsius).

Across the region, store shelves were picked clean of food and storm-related supplies such as shovels and salt as residents scrambled to prepare.

Some big employers said they were considering pleas by officials to let workers stay home, including State Street Corp, one of Boston's largest employers in the financial sector.

(Additional reporting by Daniel Lovering and Tim McLaughlin in Boston, Dave Warner in Philadelphia, Karen Jacobs in Atlanta and Colleen Jenkins in North Carolina; Editing by Daniel Trotta; and Jeffrey Benkoe)

Also Read

Source: http://news.yahoo.com/england-bear-brunt-powerful-blizzard-032605853.html

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?In The Studio,? OATV?s Renee DiResta Reflects On Her Transition From Trading To Investing

OATV"In the Studio" opens up February by hosting a former Wall Street derivatives trader turned early-stage venture investor in San Francisco.?Renee DiResta, an Associate with O'Reilly AlphaTech Ventures (OATV), is relatively new to the West Coast startup scene. After finishing a CS degree in college, she worked in the fast-paced world of trading derivatives on Wall Street. During that time, DiResta began to explore an interest in technology and startups, slowly building connections with the New York City startup community. Interestingly, as DiResta notes in this discussion, she wasn't comfortable interacting with tech folks online because, in finance, the culture is to remain quite and unseen.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/2WroAfxQpYo/

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